Vaccines have played a crucial role in combating the Covid-19 pandemic, helping to prevent severe illness and death. However, in an extremely rare case, a Covid booster shot reactivated tuberculosis (TB) in a 47-year-old man who had been living with a dormant infection. This unprecedented immune response raises questions about how vaccines interact with underlying health conditions, particularly in immunocompromised individuals.
This article explores how the Covid booster reawakened TB, the science behind immune system reactions, and what this case means for future vaccination strategies.
The Unusual Case: Covid Booster Triggers Tuberculosis
A 47-year-old man in India had been living with latent tuberculosis—a silent infection that remains in the body without causing symptoms. Before his Covid vaccinations, he showed no signs of active TB and had tested negative for the disease during routine screenings.
However, things took a shocking turn after his third Covid booster shot. Within just five days, he began experiencing severe symptoms, including:
High fever Excessive night sweats Extreme fatigue Painful swelling in his lymph nodes
Doctors initially suspected an autoimmune reaction, but further tests revealed that his dormant TB infection had become active, a rare occurrence known as tuberculosis immune reconstitution inflammatory syndrome (TB-IRIS).
Understanding TB-IRIS: A Hyperactive Immune Response
What is TB-IRIS?
TB-IRIS is a condition where a weakened immune system suddenly regains strength and aggressively attacks a dormant TB infection, causing excessive inflammation. It is most commonly seen in HIV patients when they start antiretroviral therapy, but this case suggests that Covid vaccines could also trigger similar immune responses in some individuals.
Video : Covid booster vaccine reawakens world’s deadliest virus inside man’s body
How Did the Covid Vaccine Play a Role?
Covid mRNA vaccines are designed to stimulate the immune system by mimicking viral proteins. This triggers the body to produce a strong defense against potential infections. However, in rare cases, the immune system may become too aggressive and start attacking latent infections like TB, which had previously been controlled by the body.
The man’s immune system, reawakened by the Covid booster, mistakenly identified his dormant TB bacteria as a new threat, leading to a full-blown inflammatory response.
A Misdiagnosed Condition: The Road to Discovery
Before this incident, the patient had been diagnosed with rheumatoid arthritis (RA)—an autoimmune condition that causes chronic joint pain. To treat RA, he was prescribed immunosuppressive drugs, which weakened his immune system and may have allowed TB bacteria to remain inactive.
But when he received his Covid booster, the sudden immune reactivation overwhelmed his body, making the TB infection spread rapidly and causing severe inflammation.
Symptoms That Led to a TB Diagnosis
The man’s initial symptoms were mistakenly linked to arthritis and Covid vaccine side effects. However, as his condition worsened, doctors conducted further tests, revealing:
Severe swelling in lymph nodes (especially in the neck) CT scan abnormalities indicating TB inflammation Biopsy confirming tuberculosis
He was immediately placed on a four-drug TB treatment plan, which led to significant improvement within five days.
A Second Shock: TB Symptoms Return After Third Booster
Just two weeks later, the man received his third Covid booster shot—and his TB symptoms returned even more aggressively.
Severe chills and fever Uncontrollable night sweats Extreme weakness
This time, doctors quickly identified TB-IRIS as the cause. His immune system had once again been overstimulated, leading to a dangerous inflammatory reaction.
How Was He Treated?
Doctors acted fast to control his immune response while keeping his TB treatment on track. His treatment plan included:
High-dose intravenous (IV) steroids for five days to calm the immune system A slow transition to oral steroids for three months Continued TB medication for over a year
By his 18-month follow-up, his TB symptoms had fully disappeared, and he was finally able to resume arthritis treatment.
Video : A man deliberately got 217 Covid shots. Here’s what happened
What Does This Mean for Future Vaccinations?
This case does not mean that Covid vaccines cause tuberculosis. Instead, it highlights how vaccines can trigger unexpected immune responses in individuals with hidden or latent infections.
Key Takeaways for Patients with Immune Conditions:
Screening before vaccination: Patients with a history of autoimmune disorders, chronic infections, or immunosuppressive treatments should consult their doctors before getting a booster shot. Monitoring for post-vaccine symptoms: If unusual symptoms occur after a vaccine, immediate medical attention is crucial to prevent severe complications. Individualized vaccination approaches: Not everyone reacts to vaccines the same way. High-risk patients may require adjusted booster schedules or additional monitoring.
Other Inflammatory Reactions Linked to mRNA Vaccines
While mRNA vaccines are highly effective, there have been reports of immune-related side effects, including:
Myocarditis (heart muscle inflammation) Pericarditis (inflammation around the heart lining) Autoimmune disease flare-ups in some individuals
This does not mean vaccines are dangerous, but rather that certain individuals with pre-existing immune conditions may need extra precautions when receiving booster shots.
Final Thoughts: A Rare but Important Medical Case
This case of TB reactivation after a Covid booster is an extremely rare occurrence, but it serves as a reminder of how complex the human immune system is.
While vaccines remain a crucial tool in fighting infectious diseases, this case highlights the importance of personalized medicine—tailoring vaccination plans to each individual’s unique health condition.
If you or someone you know has a history of autoimmune disease, chronic infections, or immune-related conditions, it’s always best to consult a doctor before receiving a booster shot. Awareness and proactive healthcare can prevent rare complications while still ensuring protection against deadly viruses.
What are your thoughts on this case? Have you or someone you know experienced an unusual immune reaction after a vaccine? Let us know in the comments!
Meet the two kids Sandra Bullock raised with late partner, Bryan Randall
In 2010, Sandra Bullock received a phone call that changed her life forever. “Your placement is here,” said the voice on the other end.
A few weeks later, she was on a stage, accepting her first Oscar for her appearance in The Blind Side, but she didn’t care she was there. “All I wanted was to go was just go home and feed Lou” she said of her newborn, whom she had been waiting for years to arrive.
Keep reading to learn more about this incredible actor and what inspired her to adopt two children!
In 2005, after Hurricane Katrina devastated Louisiana by flooding its grounds, Sandra Bullock had a feeling that inspired her decision to adopt a child.
“Katrina happened in New Orleans, and something told me, ‘My child is there.’ It was weird,” Bullock said in an interview with Today’s Hoda Kotb.
Years later, in January 2010, Bullock received the call she had been waiting years to receive.
Years later, in January 2010, Bullock received the call she had been waiting years to receive.
“He was unexpected, he was not planned. I got a call one day, ‘Your placement is here,’ and that’s after years after having filed it, years,” the 59-year-old star of Speed tells CBS News.
Little Lou
Gushing over Louis Bardo Bullock, the three-month-old boy from New Orleans she secretly adopted in 2010, Bullock said, “I looked at him like, ‘Oh, there you are.’ It was like he had always been there,” she recalled. “He fit in the crook of my arm. He looked me in the eyes. He was wise. My child was wise.”
The Miss Congeniality star adds, “The beautiful thing that I was constantly told was, ‘The perfect child will find you. You will find your child.’ But you don’t believe that when it’s not happening. When you’re going, ‘Where is my family?’ When it does happen, you know exactly what they’re talking about.”
Weeks after Lou arrived, Bullock was on stage at the Kodiak Theatre, accepting her first Oscar for her starring role in the film, The Blind Side.
But Lou owned her center stage and she wanted to be at home, with him.
“All I kept thinking about was, ‘He’s at home.’ Like, I didn’t care. I didn’t care that I was there, I just wanted to go home. And then I was sewn in the dress. I was sewn in the dress, and I had to get myself out of the dress, but all I wanted to do was just go home and feed Lou.”
Only days after, her marriage to reality star Jesse James came crashing down and Bullock became a single mother to an infant.
Bullock said, “I mean, so much had happened. How do you process grief and not hurt your child in the process? It’s a newborn, they take on everything that you’re feeling. So, my obligation was to [Lou] and not tainting the first year of his life with my grief.”
‘Louis’ got the stage’
“No one understands the shift in priorities about having a child in your life … until you have a child in your life,” Bullock said of shifting her focus from career to mom. “It naturally shifts…he showed up and now, Louis’ got the stage.”
Growing up in a healthy, happy environment, little Lou one day looked up at mom and predicted “I’m going to have a baby soon.”
Though Bullock admits she wasn’t planning on growing her family, she listened to her son, who planted the seed.
“I realized at that time, maybe he knew something. And when I think about it, it would have been around the time that Laila was born,” Bullock said. “It’s Louis’ way. Louis has a very strong way. He’s a fine leader, and he led me to Lai.”
Laila, who was living in foster care in Louisiana, is her daughter who joined the family in 2015 when she was three.
Recalling Laila’s trauma from being in childcare, the Ocean’s 8 star said, “She’d be in the closet with all her clothes on, she’d be on a bookshelf, she’d be hiding, she’d always be ready to leave,” the actress recalled of her daughter, adding that she always made sure Laila knew that she wasn’t “going anywhere.”
She then shared a conversation she had about Laila with Bryan Randall, the father figure to her children, and her partner from 2015 until ALS claimed his life in 2023. She said, “My partner said to me, ‘When she’s been with us longer than she hasn’t been, I have a feeling we’re going to see a change.’”
He was right. Recently, Bullock described Laila as “unafraid.”
“She’s a fighter, and that’s the reason she’s here today. She fought to keep her spirit intact. Oh my God, what she is going to accomplish. She’s going to bring some real change.”
Lou, now 13, “is super sensitive…He’s wise and kind,” the Bird Box star tells People. “I saw that when they handed him to me. There was a spiritual bigness to him.”
Though fans will be disappointed, the versatile actor is scaling back her work schedule to again be a single mother.
Bullock last appeared in 2022’s The Lost City with Channing Tatum and Bullet Train with Brad Pitt.
“I can be creative, I can be part of a community, but right now, work in front of the camera needs to take a pause,” she said.
What do you think of Sandra Bullock and her little family? Please share your thoughts with us and then share this story so we can hear what others have to say!
Leave a Reply