There’s something uniquely moving about weddings that often brings tears of joy to everyone involved. Four-year-old Gage learned this lesson in a profound way during his father, US Marine Corps Sergeant Joshua Newville’s wedding to Senior Airman Emily Leehan in Ripley, New York, a few years back.
Little Gage was doing a great job of holding it together until the moment his father’s bride began reciting vows she had personally written for him. That’s when the emotions hit him hard.
As Gage stood proudly by his father’s side during the ceremony, he had no idea that Leehan had prepared a special set of vows just for him. When she began to share them in front of a teary-eyed audience, it quickly became overwhelming for the little boy.
As Leehan started: “I want you to be safe, and to try your hardest and to be a good person”, Gage could no longer contain himself and burst into tears, throwing his arms around her.
The audience collectively gasped, responding with a heartfelt “awww” as Leehan tried to comfort him, saying: “Don’t cry, baby”. At that moment, it was clear that Gage’s emotional outpouring was entirely understandable.
Leehan continued: “The last thing I hope you learn is that you are a special boy. You are so extremely smart, handsome, and kind to others. You have helped shape me into the woman that I am today, and while I may not have given you the gift of life, life certainly gave me the gift of you”.
It wasn’t just Gage who was overcome; both Leehan and Newville shed tears as they continued with their vows. Gage certainly captured the spotlight, not just with his adorable suit and innocent gaze, but also with a reaction that is sure to resonate with viewers everywhere.
According to ABC7, the newlyweds, Leehan and Newville, returned to active duty immediately after their wedding and couldn’t head off for a honeymoon right away. Instead, they went back to Joint Base McGuire-Dix-Lakehurst to begin their married life.
Despite the busy schedule, their ceremony was unforgettable. You can watch the heartwarming video of Gage’s reaction to Leehan’s vows below, be sure to have some tissues handy! It was a truly beautiful ceremony and a poignant reminder of love’s incredible power. We wish Joshua and Emily all the best in their journey together.
We’ve All Waited for It: Scientists Created a Drug That Can Help Regrow Lost Teeth
The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
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