Brian, Margaret’s conceited neighbor, had no clue the intense, deliberate reaction he would inspire when he filled in her cherished pond while she was gone. Margaret, an elderly woman who appeared to be lonely, came up with a scheme that completely changed Brian’s life. Let me tell you, having seen my fair share of drama, at seventy-four years old. However, nothing could have equipped me for the chaos that broke out in my own backyard.
I’m Margaret, and I’ve spent the last 20 years residing in this quaint little home. It’s been my little piece of paradise, where I’ve seen my three children grow up and now greet my seven grandchildren for weekend cookouts and summer splashes. There is always someone stopping by, bringing love and laughter into the space. The jewel in the crown of my estate? A lovely pond that my beloved grandfather excavated by himself. It has always served as the focal point of our family get-togethers. The grandchildren enjoy playing in it, and to be honest, there are moments when I feel like they care more about the pond than they do about me! Before roughly five years ago, when Brian moved in next door, everything was fine and dandy. That man had a bee in his bonnet about my pond from the very beginning. He would call out across the fence, “Margaret!” I can’t stop staring at those frogs all night! Is there nothing you can do about them? “Oh, Brian, they’re just singing you a lullaby,” I would merely answer with a smile. Without charge!” He, however, was not having it. “And the biting insects! They are proliferating in your pond like crazy! I would respond, “Now, Brian, I keep that pond cleaner than a whistle.” The source of the mosquitoes is most likely the pile of debris in your backyard. He would puff and sputter, but I would get on with my day. I was mistaken to think he would ultimately get used to it. I made the decision to go see my sister who lives in the next state over one day. I was excited for a few days of gin rummy and gossip. I had no idea that when I returned, I would see something that would chill me to the bone.
Upon entering my driveway, I became aware of an irregularity. There was no longer the typical shimmer of water to greet me. It was replaced by… dirt. I heaved myself out of the car, my heart sinking to my toes.Sweet old Mrs. Johnson, my neighbor across the street, hurried over. “Ah, Margaret! I’m so happy you’re back. They claimed to be following directions when I sought to stop them. “Who should stop? What directives?” I was lost in thought, gazing at the muddy area that once held my cherished pond. “Yesterday, a crew stopped by. According to Mrs. Johnson, “some company hired them to empty and refill the pond.” “They had all the paperwork, but I told them you weren’t at home!” I had been taken completely by surprise. In a day, twenty years’ worth of memories vanished. And I knew just who was responsible. I whispered, squeezing my fists, “Brian.” “How are you going to proceed?” With concern imprinted on her features, Mrs. Johnson inquired. I positioned my shoulders squarely. “Well, I’ll let you know what I plan to do. Does that man believe he can bully a kind elderly woman? He’s going to discover the hard way why you never cross a woman like Margaret! I started by giving my relatives a call. Lisa, my daughter, was furious. “Mom, this is not right! We must dial the police number! I said, “Hold your horses, sweetie.””First, we need proof.” Jessie, my granddaughter, spoke forward at that point. “Grandmother! Do you recall the bird camera we installed in the oak tree? Perhaps something got caught in it! As luck would have it, that tiny camera ended up being our covert tool. After watching the video, we could clearly see Brian leading a team to fill up my pond. He appeared to be a young child who had just avoided getting caught stealing cookies from the jar. “You got it,” I said, a smile forming on my face. Brian appeared to assume that since I’m elderly and live alone, I’d just accept it. He had no idea that I was hiding a few tricks from him. My initial action was to give the local environmental department a call. “Hi,” I said in a kind voice. “I want to report that a protected habitat has been destroyed.” Confusion was audible from the individual on the other end. “Habitat protected, ma’am?” “Oh yeah,” I answered. You see, there was a rare species of fish living in my pond. Years ago, I registered it with your organization. And without authorization, someone simply filled it in.When it comes to endangered animals, those agency people don’t play around, I can assure you. After a few days, they were at Brian’s door demanding an eye-watering fine. “We represent the Environmental Protection Agency, sir,” one of the representatives stated. “The illegal destruction of a protected habitat on your neighbor’s property is the reason we are here.” Brian’s expression turned pallid. How come? habitat that is protected? It was merely a pond. “Mr. Thompson, a pond that was home to a rare species of fish that was registered.” We have proof that you destroyed it without the required authority.”This is absurd!” Brian’s voice rose as he sputtered. “That elderly woman’s pond was a bother! I was being helpful to the neighborhood!That “favor,” sir, carries a $50,000 penalties for breaking environmental protection regulations. Brian was in complete shock. “Fifty thou—You have to be kidding! It’s all a miscommunication. The pond was that. I overheard their chat in private and had to smile. I wasn’t finished, though. With all due respect, my grandson Ethan is a highly successful lawyer in the city. I rang him. “Ethan, sweetie,” I spoke. “How about helping your grandmother take a stern look at a bully in the neighborhood?” Ethan was only too glad to assist. Brian was issued with papers for mental distress and property damage before he could pronounce “frivolous lawsuit.” I could have stopped there, but I needed to play one more card.
Karen, Brian’s wife, had always seemed like a good person. I decided it was time for a quick conversation after seeing her get home from work one evening. “Evening, Karen,” I murmured. “A moment, please?” Despite her fatigue, she managed a smile. Naturally, Margaret. What are your thoughts?I told her the truth about the pond and invited her over for a cup of tea. I told her about the fish and frogs, the kids learning to swim in it, my grandfather digging it, and the summer nights spent by it. As I spoke, Karen’s expression changed from bewildered to horrified. “Margaret, I didn’t know,” she exclaimed. “Brian informed me that the pond was filled per the city’s order for security.” “All right,” I patted her hand. “You understand the truth now.” The days that followed were peaceful. When Brian’s automobile vanished, the rumors in the neighborhood spread like wildfire. Word got out that after finding out what Brian had done, Karen had asked him to leave. Then, one morning, I heard equipment rumbling when I woke up. I almost lost my balance when I glanced out my window. My yard was being worked by a crew, and they were digging! Running outside, I saw Karen in charge of everything. She grinned at the sight of me. “Good morning, Margaret. If it’s okay with you, I felt that it was time to make things right. It came out that Karen had contracted with workers to fix my pond. She confided in me while we observed them at work. She murmured, “Brian’s been involved in some shady business dealings.” “He was simply lashing out at his own problems, which is what led to the whole pond thing.”Nevertheless, the environmental office dismissed its allegations after the pond was repaired. Ethan also persuaded me to drop the lawsuit in the interim. That boy has a gift for language. Brian, on the other hand, with his tail between his legs, skulked off to another state. Karen, however, started to visit frequently. She even began assisting me with pond maintenance, claiming it was the least she could do. Karen turned to face me and a twinkle appeared in her eye as we sat by the recently rebuilt pond one evening, watching the sunset reflected off the water. “You know, Margaret, I’m glad Brian messed with your pond. I never thought I’d say this.” I arched an eyebrow. Oh, I see. And why is it the case? She grinned. “Because I might not have realized what a wonderful neighbor I had right next door if he hadn’t.” We chuckled and clinked our glasses of iced tea. Who would have guessed that a small pond could be both so troublesome and beneficial? Thus, here I am, seventy-four years old, with a pond that has been restored, a new buddy, and a tale that will be discussed for years to come at family get-togethers. Indeed, life has a way of taking you by surprise. If there’s one thing to take away from all of this, believe me when I say this: you should never undervalue a resentful grandmother and a capable family lawyer!
We’ve All Waited for It: Scientists Created a Drug That Can Help Regrow Lost Teeth
The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
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